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U0126 (CAS: 109511-58-2)
Catalog #£ºEBC51091
  SKU-Pack Size Availability Size Price
EBC51091-1MG In Stock 1mg €76.70 / €53.69
EBC51091-5MG In Stock 5mg €141.70 / €99.19
EBC51091-10MG In Stock 10mg €206.70 / €144.69
EBC51091-25MG In Stock 25mg €362.70 / €253.89
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Product Information
Synonym(s) U-0126, U 0126
Chemical Name 2,3-bis[amino[(2-aminophenyl)thio]methylene]-butanedinitrile
Application U0126 is a highly selective, non-ATP competitive MAP Kinase Kinase (MKK, MEK1 and MEK2) and ERK inhibitor.
CAS Number 109511-58-2
Purity ¡Ý99.0%
Molecular Weight 380.49
Molecular Formula C₁₈H₁₆N₆S₂
SMILES NC1=CC=CC=C1S/C(N)=C(C#N)/C(C#N)=C(N)/SC2=CC=CC=C2N
Target & IC50 MEK1: IC50 = 72 nM
MEK2: IC50 = 58 nM
Solubility DMSO: (>10 mg/ml)
Ethanol: (2 mg/ml)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.6282 ml 13.1410 ml 26.2819 ml
5 mM 0.5256 ml 2.6282 ml 5.2564 ml
10 mM 0.2628 ml 1.3141 ml 2.6282 ml
50 mM 0.0526 ml 0.2628 ml 0.5256 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

U0126 is a selective MAPK and ERK inhibitor, displaying a preference for MEK1 and MEK2. The IC50 value for MEK1 is 72nM and MEK2 is 58nM. It is known that U-0126 binds to MAPK noncompetitive manner compared to ATP. Studies suggest that U-0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U-0126 has been observed to inhibit promoters containing an AP-1 response element. Conversely, U-0126 has no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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