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Metformin Hydrochloride (CAS: 1115-70-4)
Catalog #£ºEBC51741
  SKU-Pack Size Availability Size Price
EBC51741-1ML In Stock 1mL(10mM in DMSO) €63.70
EBC51741-1G In Stock 1g €76.70
EBC51741-10G In Stock 10g €115.70
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Product Information
Synonym(s) 1,1-Dimethylbiguanide, Hydrochloride, Metformin HCl
Chemical Name N,N-Dimethylimidodicarbonimidic diamide hydrochloride
Application Metformin hydrochloride is a antihyperglycemic biguanide with diverse biological activities, including the stimulation of AMPK
CAS Number 1115-70-4
Purity ¡Ý98.0%
Molecular Weight 165.63
Molecular Formula C₄H₁₂ClN₅
SMILES NC(NC(N(C)C)=N)=N.Cl
Target & IC50 Streptokinase A: EC5050 = 5.65 ¦ÌM
Solubility Water: 32 mg/mL (193.21 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 6.0379 ml 30.1896 ml 60.3792 ml
5 mM 1.2076 ml 6.0379 ml 12.0758 ml
10 mM 0.6038 ml 3.0190 ml 6.0379 ml
50 mM 0.1208 ml 0.6038 ml 1.2076 ml
Shipping Gel Pack
Storage Store at 4¡ã C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Metformin hydrochloride is a biguanide antihyperglycemic agent. Through glucose clamp investigation in rats 1,1-Dimethylbiguanide, Hydrochloride has been shown to lower blood glucose levels through improved glucose tolerance without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. 1,1-Dimethylbiguanide, Hydrochloride reduces the diabetic complications on the cardiovascular system and increases insulin sensitivity. 1,1-Dimethylbiguanide, Hydrochloride has been shown not to change the synthesis of either GLUT4 or GLUT1 but does stimulate the transport of GLUT1 to the plasma membrane as seen in skeletal muscles. 1,1-Dimethylbiguanide, Hydrochloride has also been observed to improve peripheral arterials through selective reduction of PAI- 1 (plasminogen activator inhibitor). In Xenopus oocytes, 1,1-Dimethylbiguanide, Hydrochloride has been documented to act by increasing intercellular calcium concentration in addition to elevating receptor tyrosine kinase activity and inositol 1,4,5-trisphosphate. 1,1-Dimethylbiguanide, Hydrochloride has demonstrated the ability to induce fatty acid oxidation and to stimulate AMP-activated protein kinase leading to the reduction in acetyl-CoA carboxylase activity. In brown adipocytes 1,1-Dimethylbiguanide, Hydrochloride has been observed to inhibit leptin secretion via a mitogen-activated protein kinase signalling pathway.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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