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AICAR (CAS: 2627-69-2)
Catalog #£ºEBC51013
  SKU-Pack Size Availability Size Price
EBC51013-1ML In Stock 1mL(10mM in DMSO) €63.70
EBC51013-50MG In Stock 50mg €63.70
EBC51013-200MG In Stock 200mg €141.70
EBC51013-1G In Stock 1g €401.70
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Product Information
Synonym(s) AICA Riboside, Acadesine, AICAR, NSC105823
Chemical Name 5-Amino-1-[(2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl]-1H-imidazole-4-carboxamide
Application AICAR is an inhibitor of the transcription of PPAR¦Á, the coactivation of PPAR¦Á
CAS Number 2627-69-2
Purity ¡Ý99.0%
Molecular Weight 258.23
Molecular Formula C₉H₁₄N₄O₅
SMILES C1=NC(=C(N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N)C(=O)N
Target & IC50 AMPK, Autophagy
Solubility DMSO: 51 mg/mL (197.50 mM)
Water: 20 mg/mL (77.45 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.8725 ml 19.3626 ml 38.7252 ml
5 mM 0.7745 ml 3.8725 ml 7.7450 ml
10 mM 0.3873 ml 1.9363 ml 3.8725 ml
50 mM 0.0775 ml 0.3873 ml 0.7745 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

AICAR is an adenosine analog that is phosphorylated in whole cells to form 5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5′-monophosphate (ZMP), which stimulates AMPK activity1. AICAR acts by entering nucleoside pools, significantly increasing levels of adenosine during periods of ATP breakdown. AICAR mimics the effects of insulin on the expression of two gluconeogenic genes PEPCK and glucose-6-phosphatase2. AICAR inhibits PPARα coactivation3 and adipocyte differentiation4. AICAR is a substrate for the AICAR transformylase activity of ATIC5. AICAR is also known as 5-amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide, N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide, and Acadesine.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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