USA:(540) 808-3925
China:400-117-0038
United States
Shopping Cart
Sign in \ Register
Actinomycin D (CAS: 50-76-0)
Catalog #:EBC51004
  SKU-Pack Size Availability Size Price
EBC51004-1ML In Stock 1mL(10mM in DMSO) $358.50
EBC51004-5MG In Stock 5mg $88.50
EBC51004-10MG In Stock 10mg $133.50
EBC51004-50MG In Stock 50mg $538.50
If you want to get a larger packsize, Please contact your local distributor or
email us atinfo@ebiocell.com
Please Select The Country You Are In To Find Your Local Distributor.
EbioCell Phone:(540) 808-3925
Imperial Business Park 4819 Emperor Boulevard, E-mail:order@ebiocell.com
United States Suite 408 Durham, NC 27703, USA Web:www.ebiocell.com
Product Information
Synonym(s) Dactinomycin, Act D, RASP-101, Oncostatin K
Chemical Name 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
Application Actinomycin D is a metabolite, apoptosis inducer, and potent antibiotic that binds to the GpC steps of DNA
CAS Number 50-76-0
Purity ≥98%
Molecular Weight 1255.42
Molecular Formula C₆₂H₈₆N₁₂O₁₆
SMILES CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
Target & IC50 cell cycle: IC50=0.4 nM
DNA repair: IC50=0.42 nM
Solubility DMSO: 100 mg/mL (79.65 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 0.7966 ml 3.9828 ml 7.9656 ml
5 mM 0.1593 ml 0.7966 ml 1.5931 ml
10 mM 0.0797 ml 0.3983 ml 0.7966 ml
50 mM 0.0159 ml 0.0797 ml 0.1593 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Actinomycin D is a metabolite isolated from Streptomyces parvulus. Actinomycin D binds to the GpC steps of DNA. Actinomycin D acts as an antibiotic, and is more effective against gram positive bacteria than gram negative bacteria. Actinomycin D can induce apoptosis in several cell lines such as lung and prostate cancer lines, and human blood lymphocytes, among others. In studies, it has been observed that Actinomycin D elevates p53 expression, leading to the increase of PUMAα/β (the p53 upregulated modulator of apoptosis protein; PUMA). Actinomycin D can also induce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced caspase-dependent and -independent apoptosis.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
Copyright 2015 EbioCell, Inc. All Rights Reserved.  备案号:津ICP备2022005142号-1