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A-769662 (CAS: 844499-71-4)
Catalog #:EBC51011
  SKU-Pack Size Availability Size Price
EBC51011-1ML In Stock 1mL(10mM in DMSO) $103.50
EBC51011-2MG In Stock 5mg $88.50
EBC51011-10MG In Stock 10mg $118.50
EBC51011-25MG In Stock 25mg $208.50
EBC51011-50MG In Stock 50mg $373.50
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Product Information
Synonym(s) A769662, A 769662
Chemical Name 6,7-dihydro-4-hydroxy-3-(2′-hydroxy[1,1′-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
Application A-769662 is an AMPK activator which induces PI3-kinase-dependent glucose uptake and inhibits AMPK dephosphorylation.
CAS Number 844499-71-4
Purity ≥99.0%
Molecular Weight 360.39
Molecular Formula C₂₀H₁₂N₂O₃S
SMILES C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O
Target & IC50 AMPK EC50= 0.8 μM
Solubility DMSO: 36 mg/mL (100 mM)
Ethanol: 3.6 mg/mL (10 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.7748 ml 13.8739 ml 27.7477 ml
5 mM 0.5550 ml 2.7748 ml 5.5495 ml
10 mM 0.2775 ml 1.3874 ml 2.7748 ml
50 mM 0.0555 ml 0.2775 ml 0.5550 ml
Shipping Gel Pack
Storage Store at 4° C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

A-769662 is an AMP-activated protein kinase (AMPK) activator that mimics the function of AMP on AMPK β-1 by allosteric activation and the inhibition of dephosphorylation of AMPK. In the prescence of both LKB1 and A-769662, the phosphorylation of AMPK is suppressed. In addition, A-769662 is not effected by upstream kinases such as calmodulin-dependent protein kinase kinase-β when phosphorylating AMPK beta-1. In vitro tests indicate A-769662 suppresses the activity of Sodium-Potassium Adenosine Triphosphatase by inhibiting the α(1)-isoform of the pump and decreasing the cell surface abundance of the protein complex in skeletal muscle cells and induces glucose uptake through a PI3-kinase-dependent pathway.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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