Protein Inhibitors - IWP-4 (CAS: 686772-17-8)

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IWP-4 (CAS: 686772-17-8)

Catalog #：EBC51122

IWP-4 (CAS: 686772-17-8)

SKU-Pack Size	Availability	Size	Price
EBC51122-1ML	In Stock	1mL(10mM in DMSO)	€245.70
EBC51122-1MG	In Stock	1mg	€76.70
EBC51122-5MG	In Stock	5mg	€180.70
EBC51122-10MG	In Stock	10mg	€258.70
EBC51122-25MG	In Stock	25mg	€518.70

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Product Information

Synonym(s)

Inhibitor of Wnt Production-4, IWP 4, IWP4

Chemical Name

N-(6-Methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4- oxothieno[3,2-d]pyrimidin-2-yl]thio]acetamide

Application

IWP-4 is a Wnt pathway inhibitor

CAS Number

686772-17-8

Purity

≥98.0%

Molecular Weight

496.62

Molecular Formula

C₂₃H₂₀N₄O₃S₃

SMILES

O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5OC)=O

Target & IC50

Wnt: IC50 = 25 nM

Solubility

DMSO: 2 mg/ml

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.0136 ml	10.0680 ml	20.1359 ml
5 mM	0.4027 ml	2.0136 ml	4.0272 ml
10 mM	0.2014 ml	1.0068 ml	2.0136 ml
50 mM	0.0403 ml	0.2014 ml	0.4027 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

IWP-4 is a potent inhibitor of Wnt production that blocks Wnt pathway activity in vitro (IC₅₀ = 25 nM). IWP-4 inactivates Porcupine (porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 μM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin. IWP-4 has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol