Protein Inhibitors - Dimethyloxaloylglycine (CAS: 89464-63-1)

Dimethyloxaloylglycine (CAS: 89464-63-1)

Catalog #：EBC51087

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Product Information

Synonym(s)

DMOG, Dimethyloxallyl glycine, N-(methoxyoxoacetyl)-glycine methyl ester

Chemical Name

N-(2-Methoxy-2-oxoacetyl)glycine methyl ester

Application

Dimethyloxaloylglycine is an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase

CAS Number

89464-63-1

Purity

≥99%

Molecular Weight

175.14

Molecular Formula

C₆H₉NO₅

SMILES

COC(=O)CNC(=O)C(=O)OC

Target & IC50

prolyl-4-hydroxylase: IC50 = 5.18 μM

Solubility

DMSO: 17.5 mg/mL (100 mM)
Ethanol: 35 mg/mL (199.84 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
Dimethyloxaloylglycine is a cell permeable Prolyl 4-hydroxylase (P4H) inhibitor which activates the hypoxia-inducible factor (HIF) in cultured cells. DMOG is reported to delay neuronal cell death caused by trophic factor deprivation through a HIF-1 alpha-independent, glucose-dependent mechanism.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol