Other Biochemicals - Clozapine N-oxide (CAS: 34233-69-7)

Clozapine N-oxide (CAS: 34233-69-7)

Catalog #：EBC51077

Clozapine N-oxide (CAS: 34233-69-7)

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Product Information

Synonym(s)

Clozapine (N-oxide), MZA8BK588J, N-Oxyclozapine

Chemical Name

3-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine

Application

Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration

CAS Number

34233-69-7

Purity

≥99.0%

Molecular Weight

342.82

Molecular Formula

C₁₈H₁₉ClN₄O

SMILES

CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2O)C=C(C=C4)Cl

Target & IC50

DREADDs

Solubility

DMSO: 68 mg/mL (198.35 mM)
Ethanol: 8 mg/mL (23.34 mM)
H₂O: 68 mg/mL (198.35 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
Clozapine N-oxide is a normally biologically inactive metabolite of clozapine that can be used to specifically activate DREAD receptors, engineered G-protein coupled receptors which are activated by otherwise inert drug-like small molecules. Clozapine is metabolized in the liver by the cytochrome P450 system and is a partial agonist of the serotonin receptor.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol