Protein Inhibitors - CHIR-99021 (CAS: 252917-06-9)

CHIR-99021 (CAS: 252917-06-9)

Catalog #：EBC51076

CHIR-99021 (CAS: 252917-06-9)

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Product Information

Synonym(s)

GSK-3 Inhibitor XVI

Chemical Name

6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile

Application

CHIR-99021 is a GSK-3α/β inhibitor

CAS Number

252917-06-9

Purity

≥99.0%

Molecular Weight

465.34

Molecular Formula

C₂₂H₁₈Cl₂N₈

SMILES

N#CC(C=N1)=CC=C1NCCNC2=NC=C(C3=NC(C)=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2

Target & IC50

GSK-3α: IC50 = 10 nM
GSK-3β: IC50 = 6.7 nM

Solubility

DMSO: 78 mg/mL (167.62 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
CHIR 99021 is an aminopyrimidine derivate that is a selective and potent inhibitor of glycogen synthase kinase 3 (GSK-3). It is used to maintain human and mouse stem cell lines and, in combination with other reagents, to chemically reprogram somatic cells into stem cells.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol