Protein Inhibitors - 5-Azacytidine (CAS: 320-67-2)

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5-Azacytidine (CAS: 320-67-2)

Catalog #：EBC51058

5-Azacytidine (CAS: 320-67-2)

SKU-Pack Size	Availability	Size	Price
EBC51058-1ML	In Stock	1mL(10mM in DMSO)	€63.70
EBC51058-100MG	In Stock	100mg	€50.70
EBC51058-200MG	In Stock	250mg	€76.70
EBC51058-500MG	In Stock	500mg	€154.70
EBC51058-1G	In Stock	1g	€219.70

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Product Information

Synonym(s)

Ladakamycin, NSC 102816, Vidaza

Chemical Name

4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one

Application

5-Azacytidine is a potent growth and Dnmt inhibitor

CAS Number

320-67-2

Purity

≥99.0%

Molecular Weight

244.20

Molecular Formula

C₈H₁₂N₄O₅

SMILES

NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@H](O)C1O

Target & IC50

DNMT1: IC50 = 0.2 μM

Solubility

DMSO: 48 mg/mL (196.56 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	4.0948 ml	20.4742 ml	40.9484 ml
5 mM	0.8190 ml	4.0948 ml	8.1897 ml
10 mM	0.4095 ml	2.0474 ml	4.0948 ml
50 mM	0.0819 ml	0.4095 ml	0.8190 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

5-Azacytidine (also known as 5-AzaC), a compound belonging to a class of cytosine analogues, is a DNA methyl transferase (DNMT) inhibitor that exerts potent cytotoxicity against multiple myeloma (MM) cells, including MM.1S, MM.1R, RPMI-8266, RPMI-LR5, RPMI-Dox40 and Patient-derived MM, with the half maximal inhibition concentration IC50 values of 1.5 μmol/L, 0.7 μmol/L, 1.1 μmol/L, 2.5 μmol/L, 3.2 μmol/L and 1.5 μmol/L respectively].

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol