Protein Agonists, Antagonists and Activators - 25-Hydroxycholesterol (CAS: 2140-46-7)

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25-Hydroxycholesterol (CAS: 2140-46-7)

Catalog #：EBC51049

Datasheet

25-Hydroxycholesterol
(CAS: 2140-46-7 )

SKU-Pack Size	Availability	Size	Price
EBC51049-1ML	In Stock	1mL(10mM in DMSO)	€89.70
EBC51049-5MG	In Stock	5mg	€76.70
EBC51049-10MG	In Stock	10mg	€102.70
EBC51049-25MG	In Stock	25mg	€180.70
EBC51049-50MG	In Stock	50mg	€297.70

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Product Information

Synonym(s)

25-hydroxycholesterol, (3beta)-isomer, 5-cholestene-3beta,25-diol

Chemical Name

cholest-5-ene-3β,25-diol

Application

25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells

CAS Number

2140-46-7

Purity

≥99.0%

Molecular Weight

402.65

Molecular Formula

C₂₇H₄₆O₂

SMILES

CC(C)(O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Target & IC50

HMG-CoA Reductase

Solubility

Ethanol: 20 mg/mL
Chloroform: 50 mg/mL

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.4835 ml	12.4177 ml	24.8355 ml
5 mM	0.4967 ml	2.4835 ml	4.9671 ml
10 mM	0.2484 ml	1.2418 ml	2.4836 ml
50 mM	0.0497 ml	0.2484 ml	0.4967 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

25-hydroxy Cholesterol is a dietary cholesterol derivative with a side chain substituted oxysterol that is capable of triggering the activation of many cholesterol molecules. It has been reported to activate ABCA1 signaling, atherosclerosis modulation, and induces apoptosis in human cell lines through caspases activation and bcl-2 downregulation. 25-hydroxy Cholesterol is immunomodulating and is capable of suppressing macrophage differentiation from monocytes.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol