Protein Inhibitors - AG 126 (CAS: 118409-62-4)

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AG 126 (CAS: 118409-62-4)

Catalog #：EBC51047

AG 126 (CAS: 118409-62-4)

SKU-Pack Size	Availability	Size	Price
EBC51047-1ML	In Stock	1mL(10mM in DMSO)	~~$133.50~~ / $93.45
EBC51047-5MG	In Stock	5mg	~~$103.50~~ / $72.45
EBC51047-10MG	In Stock	10mg	~~$178.50~~ / $124.95
EBC51047-25MG	In Stock	25mg	~~$373.50~~ / $261.45
EBC51047-50MG	In Stock	50mg	~~$643.50~~ / $450.45

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Product Information

Synonym(s)

Tyrphostin AG126

Chemical Name

2-[(3-Hydroxy-4-nitrophenyl)methylidene]propanedinitrile

Application

AG 126 is selectively inhibits phosphorylation of ERK 1 and ERK 2

CAS Number

118409-62-4

Purity

≥98.70%

Molecular Weight

215.17

Molecular Formula

C₁₀H₅N₃O₃

SMILES

C1=CC(=C(C=C1C=C(C#N)C#N)O)[N+](=O)[O-]

Target & IC50

epidermal GFRK: IC50 = 450 M

Solubility

DMSO: 43 mg/mL (199.85 mM)
Ethanol: 2 mg/mL (9.30 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	4.6475 ml	23.2374 ml	46.4749 ml
5 mM	0.9295 ml	4.6475 ml	9.2950 ml
10 mM	0.4648 ml	2.3237 ml	4.6475 ml
50 mM	0.0930 ml	0.4647 ml	0.9295 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also acts as a cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α (TNF α) and nitric oxide in murine peritoneal macrophages. AG 126 blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate, as well as glucocorticoid-induced COX-2 activity in cells (IC₅₀ = 15.38 μM).

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol