Protein Inhibitors - Apremilast (CAS: 608141-41-9)

Apremilast (CAS: 608141-41-9)

Catalog #：EBC51039

Apremilast (CAS: 608141-41-9)

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Product Information

Synonym(s)

CC-10004, CC 10004, CC10004

Chemical Name

(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

Application

Apremilast is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.

CAS Number

608141-41-9

Purity

≥99.0%

Molecular Weight

460.5

Molecular Formula

C22H24N2O7S

SMILES

C(=O)1C2=C(C(NC(C)=O)=CC=C2)C(=O)N1[C@H](C1=CC=C(OC)C(OCC)=C1)CS(C)(=O)=O

Target & IC50

PDE4: IC50 = 74 nM
TNF-α: IC50 = 77 nM

Solubility

DMSO: 92 mg/mL (199.78 mM)（br） Ethanol: 3 mg/mL (6.51 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
Apremilast is more potent For inhibition of PDE4 compared with cAMP or cGMP hydrolysing enzymes from other PDE families. Apremilast displays a broad pattern of anti-inflammatory activity in a variety of cell types, inhibits TNF-α, IL-12 and IL-23 product

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol