Protein Inhibitors - Carfilzomib (CAS: 868540-17-4)

Carfilzomib (CAS: 868540-17-4)

Catalog #：EBC51036

Carfilzomib (CAS: 868540-17-4)

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Product Information

Synonym(s)

PR-171, proteasome inhibitor

Chemical Name

(αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]- L-phenylalaninamide

Application

Carfilzomib is an irreversible proteasome inhibitor

CAS Number

868540-17-4

Purity

≥99.0%

Molecular Weight

719.91

Molecular Formula

C₄₀H₅₇N₅O₇

SMILES

CC(C)C[C@@H](C(=O)[C@]1(CO1)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4

Target & IC50

Proteasome: IC50 = 5nM

Solubility

DMSO: 100 mg/mL (138.91 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
Carfilzomib (PR-171) is a next generation, irreversible and selective inhibitor of the chymotrypsin-like activity of the proteasome. It displays potent antineoplastic activity.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol