Protein Inhibitors - Salermide (CAS: 1105698-15-4)

Salermide (CAS: 1105698-15-4)

Catalog #：EBC51025

Salermide (CAS: 1105698-15-4)

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Product Information

Synonym(s)

Salermide

Chemical Name

N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide

Application

Salermide is an inhibitor of SIRT1, SIRT2, and HDAC

CAS Number

1105698-15-4

Purity

≥99.0%

Molecular Weight

394.47

Molecular Formula

C26H22N2O2

SMILES

CC(C1=CC=CC=C1)C(=O)NC2=CC=CC(=C2)NC=C3C(=O)C=CC4=CC=CC=C43

Target & IC50

SIRT2: IC50 = 25 μM (human)
SIRT1: IC50 = 40.3 μM (human)

Solubility

DMSO: 78 mg/mL (197.73 mM)
Ethanol (warmed with 50oC water bath) 8 mg/mL (20.28 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
Salermide is a reverse amide with strong inhibitory effects on SIRT1 (Sirtuin 1) and SIRT2 (Sirtuin 2). SIRT1/2 both belong to the family of NAD+-dependent class III histone deacetylases and are shown to target protein 53, a cell cycle regulator. Salermide is shown to induce acetylation of p53 and cause cell apoptosis. Salermide also inhibits members of HDAC3 (class III HDACs)

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol