Protein Inhibitors - YM 155 (CAS: 781661-94-7)

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YM 155 (CAS: 781661-94-7)

Catalog #：EBC51023

Datasheet

YM 155 (CAS: 781661-94-7)

SKU-Pack Size	Availability	Size	Price
EBC51023-1ML	In Stock	1mL(10mM in DMSO)	￡64.90
EBC51023-5MG	In Stock	5mg	￡53.90
EBC51023-10MG	In Stock	10mg	￡86.90
EBC51023-25MG	In Stock	25mg	￡196.90
EBC51023-100MG	In Stock	100mg	￡438.90

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Product Information

Synonym(s)

Sepantronium bromide, YM-155, YM155

Chemical Name

1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione;bromide

Application

YM 155 is an inhibitor of survivin expression and apoptosis inducer

CAS Number

781661-94-7

Purity

≥99.0%

Molecular Weight

443.26

Molecular Formula

C₂₀H₁₉BrN₄O₃

SMILES

CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]

Target & IC50

Survivin: IC50 = 0.54nM

Solubility

DMSO: 55 mg/mL (124.07 mM)
Ethanol: 6 mg/mL (13.53 mM)
Water: 89 mg/mL (200.77 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.2559 ml	11.2793 ml	22.5586 ml
5 mM	0.4512 ml	2.2559 ml	4.5117 ml
10 mM	0.2256 ml	1.1279 ml	2.2559 ml
50 mM	0.0451 ml	0.2256 ml	0.4512 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

YM155, is a novel small-molecule suppressant of surviving, the smallest member of inhibitor of apoptosis (IAP) gene family. It exhibits a potent suppressive activity against survivin but has little effect on expression levels of other IAP family members or B-cell lymphoma 2 (BCL-2) related proteins. YM155 also suppresses proliferation in a broad range of human cancer cell lines, induces tumor regression in non-small cell lung cancer (NSCLC), melanoma, bladder, aggressive non-Hodgkin lymphoma, and breast cancer xenograft models, reduces spontaneous metastases, and significantly prolongs the survival of animal harboring established metastatic tumors derived from a human triple-negative breast cancer (TNBC) cell lines.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol