Protein Inhibitors - Trichostatin A (CAS: 58880-19-6)

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Trichostatin A (CAS: 58880-19-6)

Catalog #：EBC51120

Trichostatin A (CAS: 58880-19-6)

SKU-Pack Size	Availability	Size	Price
EBC51120-1ML	In Stock	1mL(10mM in DMSO)	￡207.90
EBC51120-2MG	In Stock	1mg	￡64.90
EBC51120-5MG	In Stock	5mg	￡196.90
EBC51120-10MG	In Stock	10mg	￡306.90
EBC51120-25MG	In Stock	25mg	￡614.90

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Product Information

Synonym(s)

TSA

Chemical Name

(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide

Application

Trichostatin A is a potent and non-competitive reversible inhibitor of HDAC

CAS Number

58880-19-6

Purity

≥99.0%

Molecular Weight

302.37

Molecular Formula

C₁₇H₂₂N₂O₃

SMILES

CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C

Target & IC50

HDAC1 : IC50 = 70 nM; IL-2 gene expression : IC50 = 73 nM

Solubility

DMSO: 15.1 mg/mL (50 mM)
Ethanol: 3 mg/mL (10 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.3072 ml	16.5360 ml	33.0721 ml
5 mM	0.6614 ml	3.3072 ml	6.6144 ml
10 mM	0.3307 ml	1.6536 ml	3.3072 ml
50 mM	0.0661 ml	0.3307 ml	0.6614 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

Trichostatin A (TSA) is a potent and non-competitive reversible inhibitor of HDAC (histone deacetylase) with a Ki of 3.4 nM. In HeLa cells, Trichostatin A blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin.Trichostatin A is a useful tool for induction of hyperacetylation of cellular histones and for further elucidation of their role in gene expression. Trichostatin A is also known as TSA, and [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol