AICAR (CAS: 2627-69-2)
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SKU-Pack Size | Availability | Size | Price | |
EBC51013-1ML | In Stock | 1mL(10mM in DMSO) | €63.70 | |
EBC51013-50MG | In Stock | 50mg | €63.70 | |
EBC51013-200MG | In Stock | 200mg | €141.70 | |
EBC51013-1G | In Stock | 1g | €401.70 |
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Product Information | |||||||||||||||||||||
Synonym(s) | AICA Riboside, Acadesine, AICAR, NSC105823 | ||||||||||||||||||||
Chemical Name | 5-Amino-1-[(2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl]-1H-imidazole-4-carboxamide | ||||||||||||||||||||
Application | AICAR is an inhibitor of the transcription of PPAR¦Á, the coactivation of PPAR¦Á | ||||||||||||||||||||
CAS Number | 2627-69-2 | ||||||||||||||||||||
Purity | ¡Ý99.0% | ||||||||||||||||||||
Molecular Weight | 258.23 | ||||||||||||||||||||
Molecular Formula | C₉H₁₄N₄O₅ | ||||||||||||||||||||
SMILES | C1=NC(=C(N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N)C(=O)N | ||||||||||||||||||||
Target & IC50 | AMPK, Autophagy | ||||||||||||||||||||
Solubility | DMSO: 51 mg/mL (197.50 mM) Water: 20 mg/mL (77.45 mM) |
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Preparing Stock Solutions |
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Shipping | Gel Pack | ||||||||||||||||||||
Storage | Store at -20¡ãC | ||||||||||||||||||||
Research Use | For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use. |
Product Description | |
AICAR is an adenosine analog that is phosphorylated in whole cells to form 5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5′-monophosphate (ZMP), which stimulates AMPK activity1. AICAR acts by entering nucleoside pools, significantly increasing levels of adenosine during periods of ATP breakdown. AICAR mimics the effects of insulin on the expression of two gluconeogenic genes PEPCK and glucose-6-phosphatase2. AICAR inhibits PPARα coactivation3 and adipocyte differentiation4. AICAR is a substrate for the AICAR transformylase activity of ATIC5. AICAR is also known as 5-amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide, N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide, and Acadesine. |
Specific Protocols | |