USA：(540) 808-3925
China：400-117-0038
Order@ebiocell.com
China
Shopping Cart
Sign in \ Register
Hot Search：
Location：Home > Biochemicals > Protein Inhibitors
RepSox (CAS: 446859-33-2)
Hot product
Catalog #：EBC51009
Datasheet
RepSox (CAS: 446859-33-2)
  SKU-Pack Size Availability Size Price
EBC51009-1ML In Stock 1mL(10mM in DMSO) ￥490.00
EBC51009-5MG In Stock 5mg ￥790.00
EBC51009-10MG In Stock 10mg ￥990.00
EBC51009-25MG In Stock 25mg ￥1590.00
If you want to get a larger packsize, Please contact your local distributor or
email us atinfo@ebiocell.com
Please Select The Country You Are In To Find Your Local Distributor.
北京美瑞克生物科技有限公司 Phone：  +86 010-62890160 / 13691184142(微信同号)
2 / F, 128 malianwa North Road, Haidian District, E-mail：   mrkbio@163.com 
China Beijing China Website： www.mrkbio.com
Product Information
Synonym(s) Ladakamycin, NSC 102816, Vidaza
Chemical Name 2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
Application RepSox is an ATP-competitive inhibitor of TGF-β RI kinase
CAS Number 446859-33-2
Purity ≥98.0%
Molecular Weight 287.32
Molecular Formula C₁₇H₁₃N₅
SMILES CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1
Target & IC50 Autophosphorylation of TGF-β RI kinase: IC50 = 4 nM
ellular assay of TGF β RI kinase: IC50 = 18 nM
Solubility DMSO: 53 mg/mL (184.5 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.4804 ml 17.4022 ml 34.8044 ml
5 mM 0.6961 ml 3.4804 ml 6.9609 ml
10 mM 0.3480 ml 1.7402 ml 3.4804 ml
50 mM 0.0696 ml 0.3480 ml 0.6961 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Product Description

RepSox is a cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). TGF β RI (ALK5) Inhibitor II affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16μM), minimally. ALK5 Inhibitor II has also been used as a basal media component for culturing human Pluripotent stem cells.
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
Antibodies
Primary Antibodies
Monoclonal Antibodies
Polyclonal Antibodies
Recombinant Antibodies
Secondary Antibodies
Antibody Panels
Biochemicals
Antibiotics
Protein Agonists, Antagonists and Activators
Protein Inhibitors
Protein Substrates
Stains, Dyes and Fluorescent Reagents
Other Biochemicals
Support Products
Cell Culture Related Agents
Specialty Cell Culture Media
Primary Cell Culture Media
Basal Cell Culture Media
Contact Us
Phone：919-816-2261
Fax：1-886-598-2438
Email：ebiocell@ebiocell.com
Address： Commercial Park West 2327 Englert Dr.
Room 101-5 Durham ,NC 27713
Copyright 2015 EbioCell, Inc. All Rights Reserved. 　备案号：津ICP备2022005142号-1