Other Biochemicals - (+)-BAY-K-8644 (CAS: 98791-67-4)

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(+)-BAY-K-8644 (CAS: 98791-67-4)

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Catalog #：EBC51007

Datasheet

(+)-BAY-K-8644 (CAS: 98791-67-4)

SKU-Pack Size	Availability	Size	Price
EBC51007-1ML	In Stock	1mL(10mM in DMSO)	￡141.90
EBC51007-5MG	In Stock	5mg	￡163.90
EBC51007-10MG	In Stock	10mg	￡218.90
EBC51007-25MG	In Stock	25mg	￡493.90

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Product Information

Synonym(s)

(R)-(+)-BAY K 8644, CHEMBL105672, (R)-(+)-Bay K8644

Chemical Name

(4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

Application

(R)-(+)-Bay K 8644 is an L-type calcium channel protein blocker

CAS Number

98791-67-4

Purity

≥99%

Molecular Weight

356.30

Molecular Formula

C₁₆H₁₅F₃N₂O₄

SMILES

CC1=C([N+]([O-])=O)[C@H](C2=C(C(F)(F)F)C=CC=C2)C(C(OC)=O)=C(C)N1

Target & IC50

Ba2+ currents (IBa): IC50 = 975 nM

Solubility

DMSO: 300 mg/mL (841.99 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.8066 ml	14.0331 ml	28.0662 ml
5 mM	0.5613 ml	2.8066 ml	5.6132 ml
10 mM	0.2807 ml	1.4033 ml	2.8066 ml
50 mM	0.0561 ml	0.2807 ml	0.5613 ml

Shipping

Gel Pack

Storage

Store at -20° C

Research Use

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Description

(R)-(+)-Bay K 8644 is a L-type calcium channel protein blocker with negative inotropic effects. (R)-(+)-Bay K 8644 is an enantiomer showing opposite effects to the racemate (±)-Bay K 8644 and and (S)-(−)-Bay K8644. Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (−)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (+)-BAY-K-8644.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol