Protein Inhibitors - MG-132 (CAS: 133407-82-6)

MG-132 (CAS: 133407-82-6)

Catalog #：EBC51001

MG-132 (CAS: 133407-82-6)

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Product Information

Synonym(s)

MG132, MG 132, Z-LLL-al, Z-Leu-Leu-Leu-CHO

Chemical Name

N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide

Application

MG-132 is a potent cell-permeable 20S proteasome inhibitor

CAS Number

133407-82-6

Purity

≥98.0%

Molecular Weight

475.62

Molecular Formula

C₂₆H₄₁N₃O₅

SMILES

O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C([H])=O)CC(C)C)=O)=O)CC(C)C

Target & IC50

NF-κB: IC50 = 3 μM
Suc-LLVY-AMC: IC50 = 0.85 μM
Z-LLL-AMC: IC50 = 0.1 μM
IκBα: IC50 = 3 μM

Solubility

DMSO: 93 mg/mL (139.1 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Description
MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activato MG-132 also induces apoptosis

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol

Create Citation
1, Braun HA, et al. Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines. J Biol Chem. 2005 Aug 5;280(31):28394-401.