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|WB, IHC-P, IF/ICC
|Human, Mouse, Rat
|Host / Isotype
|TKT/Transketolase Rabbit Polyclonal Antibody detects endogenous levels of TKT/Transketolase protein.
|In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
|Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
|For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected
|TKT; HEL-S-48; HEL107; SDDHD; TK; TKT1; transketolase
|Entrez Gene ID
Transketolase (TKT) is a homodimer in the pentose phosphate pathway (PPP) that catalyzes the interketol transfer between ketoses and aldoses. This enzyme, along with transaldolase, connects the nonoxidative branch of the PPP with glycolysis. Several regions of TKT are evolutionarily conserved from gram-negative bacteria to mammals. There is evidence that hypoxic and non-hypoxic induction of HIF1-α increases the expression of TKT. Because cancer cells rely on TKT in altered cell metabolism for nucleic acid synthesis, work has been done to develop inhibitors of TKT as novel cancer treatments.
|Product Image Gallery
Western blot analysis of extracts on different cells, using TKT/Transketolase Rabbit Polyclonal Antibody (EAB14039) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Lane3: Mouse liver