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MLH1 Mouse Monoclonal Antibody
Catalog #:EAB21725
  SKU-Pack Size Availability Size Price
EAB21725-100UL In Stock 100ul 297.70
If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com
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Cambiotech Phone:+44 (0) 188 448801
Lanwades Business Park, E-mail:info@cambiotech.com
Ireland Kobenhavn K, Ireland Web:www.cambiotech.com
Product Information
Applications WB, IHC-P, IF/ICC, ELISA
Species Reactivity Human, Monkey
Host / Isotype Mouse IgG1
Clonality Monoclonal
Applications Dilutions WB=1:500-2000
IHC-P=1:100-500
IF/ICC=1:100-500
MW (kDa) 85
Conjugate Unconjugate
Specificity MLH1 Mouse Monoclonal Antibody detects endogenous levels of MLH1 protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) FCC2; MLH1; FCC-2; hMLH-1; hMLH1; HNPCC; HNPCC-2; MGC5172; MLH-1; COCA2; HNPCC2; MMRCS1; mutL homolog 1
Gene Aliases MLH1
UniProt ID

P40692

Entrez Gene ID

4292

Product Description

The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).

Product Image Gallery
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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