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Veliparib (CAS: 912444-00-9)
Catalog #:EBC51042
  SKU-Pack Size Availability Size Price
EBC51042-1ML In Stock 1mL(10mM in DMSO) 89.70
EBC51042-5MG In Stock 5mg 63.70
EBC51042-10MG In Stock 10mg 89.70
EBC51042-50MG In Stock 50mg 193.70
EBC51042-10MG In Stock 100mg 323.70
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Product Information
Synonym(s) ABT-888, NSC 737664
Chemical Name 1-[3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
Application Veliparib is a potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agents
CAS Number 912444-00-9
Purity ≥99.0%
Molecular Weight 244.29
Molecular Formula C13H16N4O
SMILES NC(C1C=CC=C2N=C([C@]3(CCCN3)C)NC=12)=O
Target & IC50 PARP-1: IC50 = 5.2 nM (human)
EOL1: IC50 = 1.08 μM (human)
SNU-5: IC50 = 3.13 μM (human)
BV-173: IC50 = 5.45 μM (human)
Solubility DMSO: 29 mg/mL(118.7 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 4.0935 ml 20.4675 ml 40.9350 ml
5 mM 0.8187 ml 4.0935 ml 8.1870 ml
10 mM 0.4094 ml 2.0468 ml 4.0935 ml
50 mM 0.0819 ml 0.4094 ml 0.8187 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Veliparib, also named as AT-888, is poly (ADP-ribose) polymerase (PARP) inhibitor and has demonstrated excellent in vivo efficacy in a broad spectrum of preclinical tumor models in combination with a variety of cytotoxic agents. PARP is involved in DNA repair and elevated PARP levels can result in resistance to cytotoxic chemotherapy and radiation. So, PARP inhibitors hold promise as chemotherapy and radiation sensitizers. ABT-888 is also active on microsatellite instability (MSI) cell lines harboring mutations in both MRE11 and RAD50 genes compared to microsatellite stable (MSS) cell lines (wild-type for both genes).

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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