SKU-Pack Size | Availability | Size | Price | |
EAB21725-100UL | In Stock | 100ul | €297.70 |
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SBT BioChem Srl | Phone£º+39 05 7156 8147 |
Via Ponte di Bagnolo, 811 Bologna, | E-mail£ºinfo@sbtbiochem.it | |
Italy | Italy | Web£ºwww.sbtbiochem.it |
Product Information | |
Applications | WB, IHC-P, IF/ICC, ELISA |
Species Reactivity | Human, Monkey |
Host / Isotype | Mouse IgG1 |
Clonality | Monoclonal |
Applications Dilutions | WB=1:500-2000 IHC-P=1:100-500 IF/ICC=1:100-500 |
MW (kDa) | 85 |
Conjugate | Unconjugate |
Specificity | MLH1 Mouse Monoclonal Antibody detects endogenous levels of MLH1 protein. |
Purification | Affinity purification |
Concentration | 1mg/ml |
Format | Liquid |
Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
Shipping | Gel Pack |
Storage | Store at -20¡ãC least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4¡ãC for 1-2 weeks. |
Research Use | For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
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Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
Product Bioinformatics | |
Synonym(s) | FCC2; MLH1; FCC-2; hMLH-1; hMLH1; HNPCC; HNPCC-2; MGC5172; MLH-1; COCA2; HNPCC2; MMRCS1; mutL homolog 1 |
Gene Aliases | MLH1 |
UniProt ID | |
Entrez Gene ID |
Product Description | |
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). |
Product Image Gallery | |
![]() Western blot analysis of extracts on different cells, using MLH1 Mouse Monoclonal Antibody (EAB21725) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
Lane1: Hela Lane2: A549 Lane3: Jurkat |
Specific Protocols | |