Veliparib (CAS: 912444-00-9)
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SKU-Pack Size | Availability | Size | Price | |
EBC51042-1ML | In Stock | 1mL(10mM in DMSO) | ¥690.00 | |
EBC51042-5MG | In Stock | 5mg | ¥490.00 | |
EBC51042-10MG | In Stock | 10mg | ¥690.00 | |
EBC51042-50MG | In Stock | 50mg | ¥1490.00 | |
EBC51042-10MG | In Stock | 100mg | ¥2490.00 |
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北京美瑞克生物科技有限公司 | Phone: +86 010-62890160 / 13691184142(微信同号) |
2 / F, 128 malianwa North Road, Haidian District, | E-mail: mrkbio@163.com | |
China | Beijing China | Website: www.mrkbio.com |
Product Information | |||||||||||||||||||||
Synonym(s) | ABT-888, NSC 737664 | ||||||||||||||||||||
Chemical Name | 1-[3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | ||||||||||||||||||||
Application | Veliparib is a potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agents | ||||||||||||||||||||
CAS Number | 912444-00-9 | ||||||||||||||||||||
Purity | ≥99.0% | ||||||||||||||||||||
Molecular Weight | 244.29 | ||||||||||||||||||||
Molecular Formula | C13H16N4O | ||||||||||||||||||||
SMILES | NC(C1C=CC=C2N=C([C@]3(CCCN3)C)NC=12)=O | ||||||||||||||||||||
Target & IC50 | PARP-1: IC50 = 5.2 nM (human) EOL1: IC50 = 1.08 μM (human) SNU-5: IC50 = 3.13 μM (human) BV-173: IC50 = 5.45 μM (human) |
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Solubility | DMSO: 29 mg/mL(118.7 mM) | ||||||||||||||||||||
Preparing Stock Solutions |
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Shipping | Gel Pack | ||||||||||||||||||||
Storage | Store at -20°C | ||||||||||||||||||||
Research Use | For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use. |
Product Description | |
Veliparib, also named as AT-888, is poly (ADP-ribose) polymerase (PARP) inhibitor and has demonstrated excellent in vivo efficacy in a broad spectrum of preclinical tumor models in combination with a variety of cytotoxic agents. PARP is involved in DNA repair and elevated PARP levels can result in resistance to cytotoxic chemotherapy and radiation. So, PARP inhibitors hold promise as chemotherapy and radiation sensitizers. ABT-888 is also active on microsatellite instability (MSI) cell lines harboring mutations in both MRE11 and RAD50 genes compared to microsatellite stable (MSS) cell lines (wild-type for both genes). |
Specific Protocols | |