The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
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Western blot analysis of extracts on COS7 cells treated with EGF, using Phospho-Cdc6 (Ser54) Rabbit Polyclonal Antibody (EAB11701) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.