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|Applications||WB, IHC-P, IF/ICC|
|Species Reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit IgG|
|Specificity||Cytokeratin 14 Rabbit Monoclonal Antibody detects endogenous levels of Cytokeratin 14 protein.|
|Formulation||In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.|
|Storage||Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.|
|Research Use||For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.|
WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected
|Synonym(s)||CK14; EBS3; EBS4; K14; NFJ; KRT14; Cytokeratin 14; CK-14; Cytokeratin14; Cytokeratin-14; Keratin-14; Keratin14; Koebner; EBS-3; EBS-4; K1C14|
|Entrez Gene ID|
Cytokeratin 14 (also designated KRT14 antibody, or Keratin 14 antibody) comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. In Bowen′s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. The gene encoding human Cytokeratin 14 maps to chromosome 17q12-21. Mutations in this gene lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.
|Product Image Gallery|
Western blot analysis of extracts on different cells, using Cytokeratin 14 Rabbit Monoclonal Antibody (EAB22608) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Lane2: Human skin