USA:(540) 808-3925
China:400-117-0038
China
Shopping Cart
Sign in \ Register
GSK-3β Rabbit Monoclonal Antibody
Catalog #:EAB21476
  SKU-Pack Size Availability Size Price
EAB21476-100UL In Stock 100ul ¥2290.00
EAB21476-200UL In Stock 200ul ¥3690.00
If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com
Please select the country you are in to find your local distributor.
北京美瑞克生物科技有限公司 Phone:  +86 010-62890160 / 13691184142(微信同号)
2 / F, 128 malianwa North Road, Haidian District, E-mail:   mrkbio@163.com 
China Beijing China Website: www.mrkbio.com
Product Information
Applications WB, IHC-P, IF/ICC, FC
Species Reactivity Human, Mouse
Host / Isotype Rabbit IgG
Clonality Monoclonal
Applications Dilutions WB=1:500-2000 
IHC-P=1:50-200 
IF/ICC=1:50-200 
FC=1:10-100
MW (kDa) 47
Conjugate Unconjugate
Specificity GSK-3β Rabbit Monoclonal Antibody detects endogenous levels of GSK-3β protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) 7330414F15Rik; 8430431H08Rik; C86142; GSK-3; GSK-3beta; GSK3; GSK3B
Gene Aliases GSK3B
UniProt ID

P49841

Entrez Gene ID

2932

Product Description

Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer′s disease. Two forms of GSK-3, designated GSK-3α and GSK-3β, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer′s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer′s disease.

Product Image Gallery
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
Copyright 2015 EbioCell, Inc. All Rights Reserved.  备案号:津ICP备2022005142号-1