SKU-Pack Size | Availability | Size | Price | |
EAB14375-30UL | In Stock | 30ul | ¥1090.00 | |
EAB14375-100UL | In Stock | 100ul | ¥2290.00 | |
EAB14375-200UL | In Stock | 200ul | ¥3690.00 |
Please select the country you are in to find your local distributor. |
北京美瑞克生物科技有限公司 | Phone: +86 010-62890160 / 13691184142(微信同号) | |
2 / F, 128 malianwa North Road, Haidian District, | E-mail: mrkbio@163.com | |
China | Beijing China | Website: www.mrkbio.com |
Product Information | |
Applications | WB, IHC-P, IF, ELISA |
Species Reactivity | Human, Rat |
Host / Isotype | Rabbit IgG |
Clonality | Polyclonal |
Applications Dilutions | WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
MW (kDa) | 208 |
Conjugate | Unconjugate |
Specificity | Phospho-BRCA1 (Ser1423) Rabbit Polyclonal Antibody detects endogenous levels of BRCA1 only when phosphorylated at Ser1423. |
Purification | Affinity purification |
Concentration | 1mg/ml |
Format | Liquid |
Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
Shipping | Gel Pack |
Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
Research Use | For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
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Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
Product Bioinformatics | |
Synonym(s) | BRCA1; BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53; BRCA-1; DNA repair associated |
Gene Aliases | BRCA1 |
UniProt ID | |
Entrez Gene ID |
Product Description | |
This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. |
Product Image Gallery | |
Western blot analysis of extracts on HT29 cells, using Phospho-BRCA1 (Ser1423) Rabbit Polyclonal Antibody (EAB14375) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue, using Phospho-BRCA1 (Ser1423) Rabbit Polyclonal Antibody (EAB14375) at 1:100 dilution.
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Specific Protocols | |