|Please select the country you are in to find your local distributor.|
|北京美瑞克生物科技有限公司||Phone： +86 010-62890160 / 13691184142(微信同号)|
|2 / F, 128 malianwa North Road, Haidian District,||E-mail： email@example.com|
|China||Beijing China||Website： www.mrkbio.com|
|Applications||WB, IHC-P, IF|
|Species Reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit IgG|
|Specificity||PTCH1 Rabbit Polyclonal Antibody detects endogenous levels of PTCH1 protein.|
|Formulation||In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.|
|Storage||Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.|
|Research Use||For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.|
WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected
|Synonym(s)||PTCH1; BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11; patched 1|
|Entrez Gene ID|
This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly.
|Product Image Gallery|
Western blot analysis of extracts on different cells, using PTCH1 Rabbit Polyclonal Antibody (EAB13935) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Lane2: Mouse muscle
Immunohistochemical analysis of paraffin-embedded Human kidney tissue, using PTCH1 Rabbit Polyclonal Antibody (EAB13935) at 1:100 dilution.
Immunohistochemical analysis of paraffin-embedded Human testis tissue, using PTCH1 Rabbit Polyclonal Antibody (EAB13935) at 1:100 dilution.