Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.
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Immunohistochemical analysis of paraffin-embedded Human tonsil tissue, using Integrin αE Rabbit Polyclonal Antibody (EAB14849) at 1:100 dilution.
Immunohistochemical analysis of paraffin-embedded Human colon tissue, using Integrin αE Rabbit Polyclonal Antibody (EAB14849) at 1:100 dilution.