This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
Product Image Gallery
Western blot analysis of extracts on NIH/3T3 cells, using 14-3-3 beta/zeta Rabbit Polyclonal Antibody (EAB10501) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Immunohistochemical analysis of paraffin-embedded Human small intestinal carcinoma tissue, using 14-3-3 beta/zeta Rabbit Polyclonal Antibody (EAB10501) at 1:200 dilution.