SKU-Pack Size | Availability | Size | Price | |
EAB10359-30UL | In Stock | 30ul | ¥1090.00 | |
EAB10359-100UL | In Stock | 100ul | ¥2290.00 | |
EAB10359-200UL | In Stock | 200ul | ¥3690.00 |
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北京美瑞克生物科技有限公司 | Phone: +86 010-62890160 / 13691184142(微信同号) | |
2 / F, 128 malianwa North Road, Haidian District, | E-mail: mrkbio@163.com | |
China | Beijing China | Website: www.mrkbio.com |
Product Information | |
Applications | WB, IHC-P, IF, ELISA |
Species Reactivity | Human, Mouse, Rat |
Host / Isotype | Rabbit IgG |
Clonality | Polyclonal |
Applications Dilutions | WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
MW (kDa) | 150 |
Conjugate | Unconjugate |
Specificity | Phospho-PLCβ3 (Ser1105) Rabbit Polyclonal Antibody detects endogenous levels of PLCbeta3 only when phosphorylated at Ser1105. |
Purification | Affinity purification |
Concentration | 1mg/ml |
Format | Liquid |
Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
Shipping | Gel Pack |
Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
Research Use | For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
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Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
Product Bioinformatics | |
Synonym(s) | SMDCD; Phospholipase C-beta-3; PLC beta 3; PLC-beta-3; PLC-beta3; PLCbeta3; PLCB3 |
Gene Aliases | PLCB3 |
UniProt ID | |
Entrez Gene ID |
Product Description | |
Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1, 4, 5-triphosphate and diacylglycerol from phosphatidylinositol 4, 5 bisphosphate. A total of eight mammalian PLC isozymes have been described (PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1 and PLC δ2). The γ-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two γ-type enzymes, but not the β and δ isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC β1, PLC β2 and PLC β3 is mediated by the a subunits of the Gq class of heterotrimeric G proteins and by certain bg G protein subunits. The regulatory mechanisms for PLC δ1 and PLC δ2 are not yet resolved. |
Product Image Gallery | |
Western blot analysis of extracts on A431 cells, using Phospho-PLCβ3 (Ser1105) Rabbit Polyclonal Antibody (EAB10359) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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Specific Protocols | |