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|Applications||WB, IHC-P, IF/ICC, FC, ELISA|
|Species Reactivity||Human, Mouse, Rat|
|Host / Isotype||Mouse IgG1|
|Specificity||E-Cadherin Mouse Monoclonal Antibody detects endogenous levels of E-Cadherin protein.|
|Formulation||In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.|
|Storage||Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.|
|Research Use||For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.|
WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin
H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish
|Synonym(s)||CDH1; Arc-1; CD324; CDHE; ECAD; LCAM; UVO; cadherin-1|
|Entrez Gene ID|
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
|Product Image Gallery|
Western blot analysis of extracts on different cells, using E-Cadherin Mouse Monoclonal Antibody (EAB21599) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
Immunohistochemical analysis of paraffin-embedded Human stomach cancer tissue, using E-Cadherin Mouse Monoclonal Antibody (EAB21599) at 1:200 dilution.