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Cyclopamine (CAS: 4449-51-8)
Catalog #：EBC51082
Datasheet
Cyclopamine (CAS: 4449-51-8)
  SKU-Pack Size Availability Size Price
EBC51082-1ML In Stock 1mL(10mM in DMSO) ￥590.00
EBC51082-5MG In Stock 5mg ￥590.00
EBC51082-10MG In Stock 10mg ￥790.00
EBC51082-25MG In Stock 25mg ￥1090.00
EBC51082-50MG In Stock 50mg ￥2390.00
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Product Information
Synonym(s) 11-Deoxojervine, Hh signaling inhibitor
Chemical Name (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a, 4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro- 3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'( 3'H)-furo[3,2-b]pyridin]-3-ol
Application Cyclopamine is a hedgehog signaling pathway and Smo inhibitor
CAS Number 4449-51-8
Purity ≥98.0%
Molecular Weight 411.63
Molecular Formula C₂₇H₄₁NO₂
SMILES CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
Target & IC50 Smoothened: IC50 = 46 nM
Solubility Ethanol : 41 mg/mL (99.61 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.4294 ml 12.1471 ml 24.2943 ml
5 mM 0.4859 ml 2.4294 ml 4.8589 ml
10 mM 0.2429 ml 1.2147 ml 2.4294 ml
50 mM 0.0486 ml 0.2429 ml 0.4859 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Cyclopamine is a steroidal alkaloid inhibitor of the hedgehog signaling pathway (Hh), an essential pathway for embryonic development. It is reported to be capable of inducing differentiation of stem cells into endocrine cells and various anti-cancer applications by suppressing excess Hh activity.
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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