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SM-164 (CAS: 957135-43-2)
Catalog #:EBC51022
  SKU-Pack Size Availability Size Price
EBC51022-1ML In Stock 1mL(10mM in DMSO) ¥5990.00
EBC51037-2MG In Stock 2mg ¥2390.00
EBC51022-5MG In Stock 5mg ¥3290.00
EBC51022-10MG In Stock 10mg ¥4190.00
EBC51022-25MG In Stock 25mg ¥7990.00
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Product Information
Synonym(s) SM 164, SM164
Chemical Name (S,3S,3'S,6S,6'S,10aS,10a'S)-N,N'-((1S,1'S)-(1,1'-(4,4'-(1,4-phenylene)bis(butane-4,1-diyl))bis(1H-1,2,3-triazole-4,1-diyl))bis(phenylmethylene))bis(6-((S)-2-(2-methylamino)propanamido)-5-oxodecahydropyrrolo[1,2-a]azocine-3-carboxamide)
Application SM-164 is a bivalent mimetic of Smac
CAS Number 957135-43-2
Purity ≥99.0%
Molecular Weight 1121.42
Molecular Formula C62H84N14O6
SMILES O=C([C@H]1N(C([C@@H](NC([C@H](C)NC)=O)CCCC2)=O)[C@]2([H])CC1)N[C@H](C3=CN(CCCCC4=CC=C(CCCCN5C=C([C@H](NC([C@@H]6CC[C@](CCCC[C@@H]7NC([C@@H](NC)C)=O)([H])N6C7=O)=O)C8=CC=CC=C8)N=N5)C=C4)N=N3)C9=CC=CC=C9
Target & IC50 XIAP: IC50 = 0.56nM(Ki)
cIAP-1: IC50 = 0.31nM(Ki)
cIAP-2: IC50 = 1.1nM(Ki)
Solubility DMSO: 5.2 mg/mL (4.64 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 0.8917 ml 4.4586 ml 8.9173 ml
5 mM 0.1783 ml 0.8917 ml 1.7835 ml
10 mM 0.0892 ml 0.4459 ml 0.8917 ml
50 mM 0.0178 ml 0.0892 ml 0.1783 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

SM-164 is developed as an anticancer agent. It plays its antitumor roles through inducing degradation of cellular inhibitor of apoptosis protein (cIAP)-1/2, antagonizing X-linked inhibitor of apoptosis protein (XIAP) and inducing TNFα–dependent apoptosis in tumor cells. SM-164 is a bivalent mimetic containing two SM-122 analogues. It binds to cIAP-1 protein containing bothBIR2 and BIR3 domains, cIAP-2 BIR3 protein and XIAP protein containing both BIR2 and BIR3 domains with Ki values of 0.31 nM, 1.1 nM and 0.56 nM, respectively. In tumor cells, treatment of SM-164 significantly reduced cIAP-1 level to undetectable levels (1nM, 60min), effectively antagonized cellular XIAP and enhanced TNFα secretion. In the MDA-MB-231 xenograft model, administration of SM-164 at dose of 5mg/kg markedly decreased cIAP-1 level within 1 hour and activated caspase-8, caspase-9 and caspase-3 at 3 hour 1.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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