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Location：Home > Biochemicals > Protein Inhibitors
NU 7441 (CAS: 503468-95-9)
Catalog #：EBC51145
  SKU-Pack Size Availability Size Price
EBC51145-1ML In Stock 1mL(10mM in DMSO) ￥890.00
EBC51145-5MG In Stock 5mg ￥490.00
EBC51145-10MG In Stock 10mg ￥890.00
EBC51145-25MG In Stock 25mg ￥1490.00
EBC51145-50MG In Stock 50mg ￥2490.00
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Product Information
Synonym(s) KU-57788, KU 57788
Chemical Name 8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one
Application NU7441 is a potent novel DNA-PK inhibitor
CAS Number 503468-95-9
Purity ≥98.0%
Molecular Weight 413.49
Molecular Formula C₂₅H₁₉NO₃S
SMILES C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56
Target & IC50 DNA-PK: IC50 = 14 nM
PI3K : IC50 = 5 μM
Solubility DMSO: 15 mg/mL (36.28 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.4184 ml 12.0922 ml 24.1844 ml
5 mM 0.4837 ml 2.4184 ml 4.8369 ml
10 mM 0.2418 ml 1.2092 ml 2.4184 ml
50 mM 0.0484 ml 0.2418 ml 0.4837 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

NU 7441 is a selective and potent DNA-PK inhibitor (IC50 14nM) and P13K inhibitor (IC50 5uM). It is reported enhance the cytotoxic effects of radiation in cancer cell lines and potentiate the effects of etoposide and doxorubicin. NU 7441 is also reported to enhance the efficiency of CRISPR-Cas9 mediated homology-directed repair (HDR) 2 to 4 fold and decrease nonhomologous end-joining (NHEJ) frequency by 2 fold. 
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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