Protein Inhibitors - L-161,982 (CAS: 147776-06-5)

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L-161,982 (CAS: 147776-06-5)

Catalog #：EBC51130

L-161,982 (CAS: 147776-06-5)

SKU-Pack Size	Availability	Size	Price
EBC51130-1MG	In Stock	1mg	￥590.00
EBC51130-5MG	In Stock	5mg	￥1990.00
EBC51130-10MG	In Stock	10mg	￥3490.00
EBC51130-50MG	In Stock	50mg	￥14790.00

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Product Information

Synonym(s)

L-161982, EP₄ receptor antagonis

Chemical Name

N-((4'-((3-butyl-5-oxo-1-(2-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-4(5H)-yl)methyl)-[1,1'-biphenyl]-2-yl)sulfonyl)-3-methylthiophene-2-carboxamide

Application

L-161,982 is an EP₄ receptor antagonist

CAS Number

147776-06-5

Purity

≥98.0%

Molecular Weight

654.72

Molecular Formula

C₃₂H₂₉F₃N₄O₄S₂

SMILES

CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1sccc1C)c1ccccc1C(F)(F)F

Target & IC50

AT1: IC50 = 0.81 nM

Solubility

Soluble in DMSO (100 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.5274 ml	7.6368 ml	15.2737 ml
5 mM	0.3055 ml	1.5274 ml	3.0547 ml
10 mM	0.1527 ml	0.7637 ml	1.5274 ml
50 mM	0.0305 ml	0.1527 ml	0.3055 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
L-161,982 is a selective EP4 receptor antagonist that blocks PGE2-induced ERK phosphorylation and cell proliferation. It is reported to inhibit PGE2-induced bone formation in rats and the anti-inflammatory properties of PGE2 in human macrophages.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol

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