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Ko 143 (CAS: 461054-93-3)
Catalog #：EBC51113
Ko 143 (CAS: 461054-93-3)
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EBC51113-1MG In Stock 1mg ￥590.00
EBC51113-5MG In Stock 5mg ￥990.00
EBC51113-10MG In Stock 10mg ￥1690.00
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Product Information
Synonym(s) BCRP inhibitor, Ko-143
Chemical Name (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester
Application Ko 143 is a selective BCRP multidrug transporter inhibitor
CAS Number 461054-93-3
Purity ≥99.0%
Molecular Weight 469.57
Molecular Formula C₂₆H₃₅N₃O₅
SMILES CC(C)C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H](NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC
Target & IC50 ABCG2: IC50 = 5 nM (human)
MRP1: IC50 = 2 μM (human)
MRP2: IC50 >50 μM (human)
Solubility DMSO: 48 mg/mL (100.22 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.1296 ml 10.6480 ml 21.2961 ml
5 mM 0.4259 ml 2.1296 ml 4.2592 ml
10 mM 0.2130 ml 1.0648 ml 2.1296 ml
50 mM 0.0426 ml 0.2130 ml 0.4259 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Ko 143 is a potent and selective ABCG2 (breast cancer resistance protein multidrug transporter, BCRP) inhibitor (EC90 = 26 nM). It displays > 200-fold selectivity over P-gp and MRP-1 transporters. Ko 143 also increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance. 
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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