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Location：Home > Biochemicals > Protein Inhibitors
SU 16f (CAS: 251356-45-3)
Catalog #：EBC51095
SU 16f (CAS: 251356-45-3)
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EBC51095-5MG 2-4 Weeks 5mg ￥1990.00
EBC51095-10MG 2-4 Weeks 10mg ￥3390.00
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Product Information
Synonym(s) SU-16f, PDGFR Tyrosine Kinase Inhibitor VII
Chemical Name (E)-3-(2,4-dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
Application SU 16f is a potent PDGFRβ inhibitor
CAS Number 251356-45-3
Purity ≥98.0%
Molecular Weight 386.44
Molecular Formula C₂₄H₂₂N₂O₃
SMILES O=C(O)CCC1=C(C)NC(/C=C2C(NC3=C\2C=CC(C4=CC=CC=C4)=C3)=O)=C1C
Target & IC50 Flk-1: IC50 = 0.14 μM
FGFR1: IC50 = 2.29 μM
PDGFRβ: IC50 = 10 nM
Solubility Soluble in DMSO (100 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.5877 ml 12.9386 ml 25.8772 ml
5 mM 0.5175 ml 2.5877 ml 5.1754 ml
10 mM 0.2588 ml 1.2939 ml 2.5877 ml
50 mM 0.0518 ml 0.2588 ml 0.5175 ml
Shipping Room Temperature
Storage Room Temperature
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

SU 16f is a selective PDGFRβ inhibitor with an IC50=10nM. In vitro studies demonstrate that SU 16f also inhibits HUVEC and NIH3T3 cell proliferation with an IC50=0.11μM. In addition, SU 16f displays 14 fold selectivity towards PDGFRβ compared to Flk-1 (VEGFR2), 229-fold over Flg (FGFR1) and 10000-fold over EGFR. SU 16f is an inhibitor of Flk-1. 
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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