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Location：Home > Biochemicals > Protein Inhibitors
ABT-263 (CAS: 923564-51-6)
Catalog #：EBC51003
Datasheet
ABT-263 (CAS: 923564-51-6)
  SKU-Pack Size Availability Size Price
EBC51003-1ML In Stock 1mL(10mM in DMSO) ￥990.00
EBC51003-5MG In Stock 5mg ￥590.00
EBC51003-10MG In Stock 10mg ￥890.00
EBC51003-50MG In Stock 50mg ￥1990.00
EBC51003-100MG In Stock 100mg ￥3490.00
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Product Information
Synonym(s) Navitoclax, ABT263, ABT 263
Chemical Name (R)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide
Application ABT-263 is a bcl-2 family protein inhibitor
CAS Number 923564-51-6
Purity ≥99%
Molecular Weight 974.61
Molecular Formula C₄₇H₅₅ClF₃N₅O₆S₃
SMILES CC1(C)CCC(=C(CN2CCN(CC2)C2=CC=C(C=C2)C(=O)NS(=O)(=O)C2=CC(=C(N[C@H](CCN3CCOCC3)CSC3=CC=CC=C3)C=C2)S(=O)(=O)C(F)(F)F)C1)C1=CC=C(Cl)C=C1
Target & IC50 EOL1: IC50 = 6.69 nM
NKM-1: IC50 = 16.99 nM
ML-2: IC50 = 19.83 nM
BV-173: IC50 = 23.14 nM
Solubility DMSO: 100 mg/mL (102.6 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.0261 ml 5.1303 ml 10.2605 ml
5 mM 0.2052 ml 1.0261 ml 2.0521 ml
10 mM 0.1026 ml 0.5130 ml 1.0261 ml
50 mM 0.0205 ml 0.1026 ml 0.2052 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

ABT-263 is a novel inhibitor of antiapoptotic BCL-2 proteins and a new promising anticancer drug candidate.
ABT-263 is active against approximately one-half of the cell lines of the PPTP in vitro panel. The median IC50 for all of the lines in the panel is 1.91 µM. Navitoclax in combination with chemotherapy agents leads most ovarian cancer cell lines a synergistic response, and enhances the caspase activation in both SK-OV-3 and IGROV-1 cell lines.
 
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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