RIP also known as RIP1, RIPK1 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. RIP protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIP functions as a key mediator in signaling pathways initiated by death receptors such as TNF receptor 1 (TNFR1) and Fas/CD95, leading to the activation of NF-κB and MAP kinases, which are important for inflammation, cell survival, and immune responses. The proper function of RIPK1 is vital, as dysregulation has been implicated in various pathological conditions including inflammatory diseases, neurodegenerative disorders, and cancer.