Caspase-11 is a crucial inflammatory caspase in mice that plays a significant role in the innate immune response, particularly in the detection of intracellular lipopolysaccharides (LPS) from Gram-negative bacteria. Upon recognition of LPS, caspase-11 becomes activated and induces pyroptosis, a form of programmed cell death characterized by cell swelling and lysis, leading to the release of pro-inflammatory cytokines like interleukin-1β (IL-1β). This process is essential for controlling bacterial infections but can contribute to pathological inflammation if unregulated. Caspase-11 also influences the synthesis of functional cytokines and has been implicated in neuroinflammatory conditions such as experimental autoimmune encephalomyelitis (EAE). Understanding the function of caspase-11 is important for insights into sepsis, neurodegenerative diseases, and other inflammatory disorders.