RARγ1 also known as RARgamma1, RARγ, RARG is a retinoic acid receptor that belongs to the nuclear hormone receptor family. RARγ1 plays a crucial role in regulating gene expression during vertebrate development and tissue differentiation, acting as a nuclear transcription factor that modulates retinoid effects, which are metabolites of vitamin A. RARγ1 interacts with retinoic acid, leading to conformational changes that facilitate DNA binding and target gene transcription. This process influences cell growth, differentiation, and apoptosis, making RARγ1 essential for proper cellular function and development. RARγ1 expression is tissue-specific, with significant roles in skin and lung tissues, where expression can be altered in pathological conditions such as lung cancer.