Monoclonal Antibodies - ABCG2 Mouse Monoclonal Antibody

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ABCG2 Mouse Monoclonal Antibody

Catalog #：EAB21135

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB21135-30UL	In Stock	30ul	￡97.90
EAB21135-100UL	In Stock	100ul	￡218.90

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IHC-P, IF/ICC, FC, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Mouse IgG1
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:100-500　 IF/ICC=1:100-500 FC=1:50-200
MW (kDa)	72
Conjugate	Unconjugate
Specificity	ABCG2 Mouse Monoclonal Antibody detects endogenous levels of ABCG2 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	ATP binding cassette subfamily G member 2; MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; CD338; GOUT1; MXR-1; CDw338; CDw388; UAQTL1; EST157481; ABCG2
Gene Aliases	ABCG2
UniProt ID	Q9UNQ0
Entrez Gene ID	9429

Product Description

ABCG2 also known as BCRP1, ABCP, MXR is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 plays a crucial role in transporting various substrates across cellular membranes using energy from ATP hydrolysis. ABCG2 confers resistance to several chemotherapeutic agents, including anthracyclines and topotecan, impacting treatment efficacy in cancer patients. ABCG2 is predominantly expressed in placenta, liver, intestine, and various stem cells, where ABCG2 regulates stem cell differentiation and maintains side population (SP) phenotype, indicating stem cell properties. ABCG2 undergoes post-translational modifications such as N-linked glycosylation, influencing stability and function, and dimerizes in vivo, highlighting a complex role in cellular processes.

Product Image Gallery
Western blot analysis of extracts on COS7, NIH/3T3 cells, using ABCG2 Mouse Monoclonal Antibody (EAB21135) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution. Immunohistochemical analysis of paraffin-embedded Human skeletal muscle tissue, using ABCG2 Mouse Monoclonal Antibody (EAB21135) at 1:100 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol