Polyclonal Antibodies - TREK-2 Rabbit Polyclonal Antibody

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TREK-2 Rabbit Polyclonal Antibody

Catalog #：EAB12127

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB12127-30UL	In Stock	30ul	€115.70
EAB12127-100UL	In Stock	100ul	€258.70
EAB12127-200UL	In Stock	200ul	€440.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

Please select the country you are in to find your local distributor.

	Betaclonal	Phone：+34 (0)91 471 6763
	29/1 Lomonosovsky Pr,	E-mail：tech@betaclonal.com
Spain	Madrid, Spain	Web：www.betaclonal.com

Product Information
Applications	WB, IHC-P, IF, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:1000-5000　 IHC-P=1:100-500　 IF=1:100-500
MW (kDa)	59
Conjugate	Unconjugate
Specificity	TREK-2 Rabbit Polyclonal Antibody detects endogenous levels of TREK-2 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Potassium two pore domain channel subfamily K member 10; TREK2; TREK-2; K2p10.1; PPP1R97; KCNK10
Gene Aliases	KCNK10
UniProt ID	P57789
Entrez Gene ID	54207

Product Description

TREK-2 also known as KCNK10 is a member of the tandem-pore potassium channel family. TREK-2 plays a crucial role in maintaining the resting membrane potential and regulating cellular excitability. TREK-2 contributes to neuronal signaling and the modulation of synaptic transmission. TREK-2 is primarily localized in the cerebellum, spleen, and testis, and TREK-2′s expression in these tissues underscores its significance in various physiological processes, including sensory transduction and the response to mechanical stimuli. TREK-2 consists of 538 amino acids and features two pore-forming domains and four transmembrane segments, which are essential for its function as a potassium channel. TREK-2 exhibits inward rectification and is activated by arachidonic acid and other unsaturated fatty acids, highlighting TREK-2′s role in cellular responses to metabolic changes.

Product Image Gallery
Western blot analysis of extracts on Jurkat, Mouse brain, Rat brain cells, using TREK-2 Rabbit Polyclonal Antibody (EAB12127) at 1:2000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution. Immunohistochemical analysis of paraffin-embedded Rat brain tissue, using TREK-2 Rabbit Polyclonal Antibody (EAB12127) at 1:200 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol