Q8N5C8

TAB3 plays a crucial role in activating NF-kB and AP-1 transcription factors, which are essential for regulating immune responses and inflammation. When TAB3 is overexpressed, TAB3 can enhance signaling pathways that lead to gene transcription involved in these processes, influencing cellular responses to proinflammatory cytokines such as TNF-α and IL-1. TAB3 interacts with TAK1, forming complexes that are pivotal for mediating effects of various stimuli, including stress and inflammatory signals. This interaction is vital for proper immune system function and cellular homeostasis, making TAB3 an important target for research in inflammation and immune-related diseases.