Hydrocortisone is the primary glucocorticoid secreted by the adrenal cortex. Hydrocortisone has three times the anti-inflammatory potency of corticosterone but much lower Na+ retention potency.Hydrocortisone plays a role in the regulation of metabolism, electrolyte balance, water balance, and the body′s stress response. It has been utilized in research to investigate the impact of inflammation and stress on cellular processes.