P51149 

Rab7 plays a crucial role in intracellular transport, particularly in late endosomal and lysosomal pathways, where Rab7 is involved in regulating vesicle trafficking and fusion processes. This function is vital for maintaining cellular homeostasis and facilitating delivery of proteins and lipids to appropriate destinations within cells. Disruptions in Rab7 function have been implicated in various diseases, including neurodegenerative disorders, highlighting Rab7′s importance in cellular health. Rab proteins, including Rab7, are part of the Ras-related superfamily of guanine nucleotide-binding proteins, which exhibit significant homology with Ras p21 and are essential for transport of newly synthesized proteins from endoplasmic reticulum to Golgi apparatus and beyond. Each member of the Rab subfamily is localized to specific stages of membrane transport pathways, underscoring the intricate regulation of cellular transport mechanisms.